propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester

Base Information

• Chemical Name: propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester
• CAS No.: 1044871-58-0
• Molecular Formula: C₂₄H₂₉N₃O₆
• Molecular Weight: 455.511
• Mol file: 1044871-58-0.mol

Synonyms:propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester

Chemical Property of propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester

There total 11 articles about propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

Propyl isocyanate (110-78-1) + 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one (1044870-39-4) → propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester (1044871-58-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 70 ℃; for 16h;

Reference yield: 41.0%

Propyl isocyanate (110-78-1) + 2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)acetic acid (1044870-92-9) → propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester (1044871-58-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 70 ℃; for 16h;

Reference yield:

2-amino-4,6-dimethoxybenzoic acid (21577-57-1) → propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester (1044871-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / tetrahydrofuran / 3 h / 20 °C

1.2: 16 h / 20 °C

2.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 14 h / 150 °C

3.1: triethylamine / tetrahydrofuran / 16 h / 70 °C

With 4-methyl-morpholine; benzotriazol-1-ol; toluene-4-sulfonic acid; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide;

upstream raw materials:

Propyl isocyanate

2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one

4,6-dimethoxyindoline-2,3-dione

4-hydroxy-3,5-dimethylbenzaldehyde