RVX-208

Base Information Edit

Chemical Name:RVX-208
CAS No.:1044870-39-4
Molecular Formula:C20H22N2O5
Molecular Weight:370.405
Hs Code.:2933990090
Mol file:1044870-39-4.mol

Synonyms:2-(4-(2-hydroxyethoxy)-3,5-diMethylphenyl)-5,7-diMethoxyquinazolin-4(3H)-one;RVX-208;RVX-000222;4(3H)-Quinazolinone, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-;2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone RVX-208;Apabetalone;Apabetalone-RVX-208;RVX-208(RVX000222)

Suppliers and Price of RVX-208

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
RVX-208
100mg
$ 1423.00

TRC
RVX208
25mg
$ 330.00

Medical Isotopes, Inc.
RVX208
10 mg
$ 650.00

Matrix Scientific
2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one 95+%
1g
$ 1344.00

DC Chemicals
RVX-208 >98%
1 g
$ 1100.00

DC Chemicals
RVX-208 >98%
250 mg
$ 600.00

DC Chemicals
RVX-208 >98%
100 mg
$ 350.00

Crysdot
RVX-208 98+%
50mg
$ 372.00

ChemScene
Apabetalone 99.86%
100mg
$ 700.00

ChemScene
Apabetalone 99.86%
25mg
$ 240.00

Total 56 raw suppliers

Chemical Property of RVX-208 Edit

Chemical Property:

Boiling Point:594.2±60.0 °C(Predicted)
PKA:14.21±0.10(Predicted)
PSA：93.67000
Density:1.28±0.1 g/cm3(Predicted)
LogP:2.59520
Storage Temp.:-20°C (des.)
Solubility.:Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).

Purity/Quality:

99% ^*data from raw suppliers

RVX-208 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a selective antagonist of BET bromodomains, binding with 10-100-fold higher affinity for BD2 (IC50 = 0.04-0.28 μM) over BD1 (IC50 = 1.8-3.1 μM). RVX-208 causes the selective release of BET proteins from chromatin in cells. It interferes with the BET protein BRD4, resulting in an increased expression of apolipoprotein (Apo) A1 in cells, mice, monkeys, and humans. RVX-208 also reduces atherosclerosis in hyperlipidemic ApoE-deficient mice.
Uses RVX-208 is a selective antagonist of bromodomain and extra terminal (BET)’s bromodomains.

Technology Process of RVX-208

There total 23 articles about RVX-208 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%