tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate

Base Information

Chemical Name:tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate
CAS No.:1389327-20-1
Molecular Formula:C₂₃H₂₈ClN₃O₃
Molecular Weight:429.947
Hs Code.:

Synonyms:tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate

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Chemical Property of tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate

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Technology Process of tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate

There total 7 articles about tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389327-19-8
tert-butyl 1-[2-(4-chlorophenyl)-1-oxobutan-2-yl]-1H-indazol-4-ylcarbamate

: 75-16-1
methylmagnesium bromide

: 1389327-20-1
tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389327-20-1
tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: lithium borohydride / tetrahydrofuran / 20 h / 0 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

7.1: diethyl ether; tetrahydrofuran / 0.5 h / 0 °C

With lithium borohydride; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; Dess-Martin periodane; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1389327-20-1
tert-butyl 1-[3-(4-chlorophenyl)-2-hydroxypentan-3-yl]-1H-indazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: lithium borohydride / tetrahydrofuran / 20 h / 0 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

7.1: diethyl ether; tetrahydrofuran / 0.5 h / 0 °C

With lithium borohydride; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; Dess-Martin periodane; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;