7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Base Information

Chemical Name:7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester
CAS No.:1418025-63-4
Molecular Formula:C₂₆H₁₉ClN₄O₃
Molecular Weight:470.915
Hs Code.:

Synonyms:7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Suppliers and Price of 7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

There total 8 articles about 7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15018-66-3
4-Aminoquinazoline

: 1402345-34-9
3-bromomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

: 1418025-63-4
7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Guidance literature:: 4-Aminoquinazoline; 3-bromomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; under 760.051 Torr; Inert atmosphere;

With sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil; at 20 ℃; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418025-63-4
7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.1: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere

3.1: potassium carbonate / methanol / 1 h / 80 °C / 760.05 Torr / Inert atmosphere

4.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 100 °C / 760.05 Torr / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

5.2: 20 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; toluene;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418025-63-4
7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere

2.1: potassium carbonate / methanol / 1 h / 80 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 100 °C / 760.05 Torr / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

4.2: 20 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; toluene;