1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide

Base Information

• Chemical Name: 1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide
• CAS No.: 138850-43-8
• Molecular Formula: C₁₇H₂₁N₂O₂*I
• Molecular Weight: 412.27
• Mol file: 138850-43-8.mol

Synonyms:1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide

Chemical Property of 1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide

There total 3 articles about 1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridine (138850-42-7) + methyl iodide (74-88-4) → 1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide (138850-43-8)

Guidance literature:

In acetonitrile; Heating;

DOI:10.1016/S0040-4020(01)80884-X

Reference yield:

3-pyridinecarbonyl chloride (10400-19-8) → 1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide (138850-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / triethylamine / CH₂Cl₂ / 3 h / 0 °C

2: 98 percent / acetonitrile / Heating

With triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(01)80884-X

Reference yield:

(S)-(+)-2-(N-methylamino)-3-phenylpropanol (84773-29-5) → 1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridinium iodide (138850-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / triethylamine / CH₂Cl₂ / 3 h / 0 °C

2: 98 percent / acetonitrile / Heating

With triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(01)80884-X

upstream raw materials:

3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonylpyridine

methyl iodide

3-pyridinecarbonyl chloride

(S)-(+)-2-(N-methylamino)-3-phenylpropanol

Downstream raw materials:

1-Methyl-3-(N,N')-<(S)-(1-benzylhydroxyethyl)methyl>aminocarbonyl-1,4-dihydropyridine