4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine

Base Information

Chemical Name:4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine
CAS No.:626218-99-3
Molecular Formula:C₃₁H₃₉ClN₄O₃S
Molecular Weight:583.195
Hs Code.:

Synonyms:4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine

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Chemical Property of 4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine

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Technology Process of 4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine

There total 7 articles about 4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 791615-55-9
[2-[4-(2-{[tert-butoxycarbonyl-(2-thiophen-2-yl-ethyl)-amino]-methyl}-phenyl)-piperazin-1-yl]-1-(4-chloro-benzyl)-2-oxo-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

: 626218-99-3
4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine

Guidance literature:: With diethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2004.08.055

Reference yield:

: 30433-91-1
[2-(2-thyenyl)ethyl]amine

: 626218-99-3
4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH(OAc)3 / CH₂Cl₂ / 16 h

2: 6.60 g / CH₂Cl₂ / 6 h

3: 35 percent / ammonia; H₂ / Pd/C / methanol / 23 h / 2068.59 Torr

4: HOBt; EDC / CH₂Cl₂ / 18 h

5: 1.11 g / diethylamine / CH₂Cl₂ / 3 h

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm049278i

Reference yield:

: 626220-82-4
4-{2-[(2-thiophen-2-yl-ethylamino)-methyl]-phenyl}-piperazine-1-carboxylic acid benzyl ester

: 626218-99-3
4-[(2R)-amino-3-(4-chlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 6.60 g / CH₂Cl₂ / 6 h

2: 35 percent / ammonia; H₂ / Pd/C / methanol / 23 h / 2068.59 Torr

3: HOBt; EDC / CH₂Cl₂ / 18 h

4: 1.11 g / diethylamine / CH₂Cl₂ / 3 h

With ammonia; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm049278i