di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate

Base Information

Chemical Name:di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate
CAS No.:935248-19-4
Molecular Formula:C₂₉H₃₃ClN₂O₆
Molecular Weight:541.044
Hs Code.:

Synonyms:di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate

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Chemical Property of di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate

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Technology Process of di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate

There total 5 articles about di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 935248-17-2
6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl-chloride

: 541-16-2
t-butyl malonate

: 935248-19-4
di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 60 ℃; for 60h;
DOI:10.1016/j.bmcl.2006.12.109

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 935248-19-4
di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / aluminum chloride / toluene / 0.5 h / Heating

2: 63 percent / potassium carbonate / tetrabutylammonium iodide / acetonitrile / 40 h / 60 - 65 °C

3: 100 percent / sodium borohydride / methanol / 1 h / 20 °C

4: 100 percent / thionyl chloride / toluene / 1.5 h / 20 - 60 °C

5: 82 percent / potassium t-butoxide / tetrahydrofuran / 60 h / 60 °C

With sodium tetrahydroborate; aluminium trichloride; thionyl chloride; potassium tert-butylate; potassium carbonate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2006.12.109

Reference yield:

: 62803-47-8
6-hydroxy-1-indanone

: 935248-19-4
di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / potassium carbonate / tetrabutylammonium iodide / acetonitrile / 40 h / 60 - 65 °C

2: 100 percent / sodium borohydride / methanol / 1 h / 20 °C

3: 100 percent / thionyl chloride / toluene / 1.5 h / 20 - 60 °C

4: 82 percent / potassium t-butoxide / tetrahydrofuran / 60 h / 60 °C

With sodium tetrahydroborate; thionyl chloride; potassium tert-butylate; potassium carbonate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2006.12.109