1,3-Dioxolane-4,5-dicarboxaldehyde, 2,2-dimethyl-, (4R,5R)- (9CI)

Base Information

• Chemical Name: 1,3-Dioxolane-4,5-dicarboxaldehyde, 2,2-dimethyl-, (4R,5R)- (9CI)
• CAS No.: 122137-20-6
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.154
• Mol file: 122137-20-6.mol

Synonyms:1,3-Dioxolane-4,5-dicarboxaldehyde,2,2-dimethyl-, (4R-trans)-

Chemical Property of 1,3-Dioxolane-4,5-dicarboxaldehyde, 2,2-dimethyl-, (4R,5R)- (9CI)

Chemical Property:

• PSA: 52.60000
• LogP: -0.09570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dioxolane-4,5-dicarboxaldehyde, 2,2-dimethyl-, (4R,5R)- (9CI)

There total 18 articles about 1,3-Dioxolane-4,5-dicarboxaldehyde, 2,2-dimethyl-, (4R,5R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3,4-O-isopropylidene-D-mannitol (3969-84-4,33493-69-5,94925-98-1) → (4S,5S)-2,2-dimethyl-[1,3]dioxolane-4,5-dicarbaldehyde (5754-27-8,85362-89-6,122137-20-6,146566-82-7)

Guidance literature:

With sodium periodate; In methanol; at 0 - 20 ℃; for 1h; phosphate buffer (pH 7.13);

DOI:10.1016/S0040-4020(01)80130-7

Reference yield:

(-)-dimethy-2,3-O-isopropylidene-L-tartrate (37031-29-1) → (4R,5R)-2,2-Dimethyl-[1,3]dioxolane-4,5-dicarbaldehyde (122137-20-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2h;

DOI:10.1021/ol050105c DOI:10.1021/ol052332k

Reference yield:

3,4-di-O-isopropylidene-D-mannitol (3969-84-4) → (4S,5S)-2,2-dimethyl-[1,3]dioxolane-4,5-dicarbaldehyde (5754-27-8,85362-89-6,122137-20-6,146566-82-7)

Guidance literature:

With sodium periodate; sodium hydrogencarbonate; for 1h; Ambient temperature;

upstream raw materials:

(1R,1'R)-1,1'-[(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl]diethane-1,2-diol

3,4-O-methylethylidene-D-mannitol

3,4-O-isopropylidene-D-mannitol

mannitol

Downstream raw materials:

(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol

(4R,5R)-4,5-diethynyl-2,2-dimethyl-[1,3]dioxolane

(4R,5R)-2,2,N,N,N',N'-hexamethyl-1,3-dioxolane-4,5-dicarboxamide

C₂₁H₂₄N₂O₄