1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

Base Information

Chemical Name:1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid
CAS No.:925688-15-9
Molecular Formula:C₁₉H₁₇F₃N₂O₄S
Molecular Weight:426.416
Hs Code.:

Synonyms:1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

There total 4 articles about 1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-[hydroxy-(2-trifluoromethyl-phenyl)-methyl]-1-isopropyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-5-carboxylic acid

: 925688-15-9
1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; at 18 - 25 ℃;
DOI:10.1021/jm060995h

Reference yield:

: 925688-13-7
1-isopropyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

: 925688-15-9
1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 3.1 g / trifluoroacetic acid; triethylsilane / 18 - 25 °C

With triethylsilane; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/jm060995h

Reference yield:

: 496792-40-6
ethyl 1-isopropyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylate

: 925688-15-9
1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 18 - 25 °C

2.1: LDA / tetrahydrofuran; hexane / -78 °C

2.2: tetrahydrofuran; hexane / 2 h / -78 °C

3.1: 3.1 g / trifluoroacetic acid; triethylsilane / 18 - 25 °C

With triethylsilane; sodium hydroxide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jm060995h