1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Name:1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:925688-17-1
Molecular Formula:C₂₂H₂₂F₃N₃O₃S₂
Molecular Weight:497.562
Hs Code.:

Synonyms:1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 6 articles about 1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925688-13-7
1-isopropyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

: 925688-17-1
1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 3.1 g / trifluoroacetic acid; triethylsilane / 18 - 25 °C

3.1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h / 18 - 25 °C

4.1: tetrahydrofuran / 18 - 25 °C

With triethylsilane; oxalyl dichloride; N,N-dimethyl-formamide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm060995h

Reference yield:

: 496792-40-6
ethyl 1-isopropyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylate

: 925688-17-1
1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 18 - 25 °C

2.1: LDA / tetrahydrofuran; hexane / -78 °C

2.2: tetrahydrofuran; hexane / 2 h / -78 °C

3.1: 3.1 g / trifluoroacetic acid; triethylsilane / 18 - 25 °C

4.1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h / 18 - 25 °C

5.1: tetrahydrofuran / 18 - 25 °C

With triethylsilane; sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm060995h

Reference yield:

: 925688-15-9
1-isopropyl-3-methyl-2,4-dioxo-6-[2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid

: 925688-17-1
1-isopropyl-3-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)-6-[2-(trifluoromethyl)benzyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h / 18 - 25 °C

2: tetrahydrofuran / 18 - 25 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm060995h