(E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine

Base Information

Chemical Name:(E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine
CAS No.:1240206-09-0
Molecular Formula:C₃₀H₂₈ClF₃N₆O₂S
Molecular Weight:629.106
Hs Code.:

Synonyms:(E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine

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Chemical Property of (E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine

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Technology Process of (E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine

There total 16 articles about (E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1239957-18-6
2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-l-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethanamine hydrochloride

: 1934-75-4
sodium dicyanamide

: 1240206-09-0
(E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine

Guidance literature:: In isopropyl alcohol; for 24h; Reflux;

Reference yield:

: 532967-21-8
2,6-difluoro-4-hydroxybenzaldehyde

: 1240206-09-0
(E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 85 °C

2: sodium tetrahydroborate / ethanol / 1 h

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h

4: hydrogen fluoride / acetonitrile / 1 h

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

6: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

7: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 5 h / 2068.65 - 2327.23 Torr

8: isopropyl alcohol / 24 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; sodium azide; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1240206-09-0
(E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine

Guidance literature:: Multi-step reaction with 13 steps

1: sulfuric acid; water / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

7: acetic acid / 4 h / Reflux

8: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h

9: hydrogen fluoride / acetonitrile / 1 h

10: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

11: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

12: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 5 h / 2068.65 - 2327.23 Torr

13: isopropyl alcohol / 24 h / Reflux

With hydrogenchloride; dmap; sodium azide; di-isopropyl azodicarboxylate; sulfuric acid; hydrogen fluoride; water; hydrogen; tetra-N-butylammonium tribromide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;