2-iodo-3-(hydroxymethyl)quinoline benzoate ester

Base Information

• Chemical Name: 2-iodo-3-(hydroxymethyl)quinoline benzoate ester
• CAS No.: 127183-66-8
• Molecular Formula: C₁₇H₁₂INO₂
• Molecular Weight: 389.192
• Mol file: 127183-66-8.mol

Synonyms:2-iodo-3-(hydroxymethyl)quinoline benzoate ester

Chemical Property of 2-iodo-3-(hydroxymethyl)quinoline benzoate ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-iodo-3-(hydroxymethyl)quinoline benzoate ester

There total 3 articles about 2-iodo-3-(hydroxymethyl)quinoline benzoate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2-iodoquinolin-3-yl)methanol (101330-11-4) + benzoyl chloride (98-88-4) → 2-iodo-3-(hydroxymethyl)quinoline benzoate ester (127183-66-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 8h;

DOI:10.1021/ja00167a047

Reference yield:

2-chloro-3-quinoline carboxaldehyde (73568-25-9) → 2-iodo-3-(hydroxymethyl)quinoline benzoate ester (127183-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / NaBH₄ / tetrahydrofuran; H₂O / 1 h / 10 °C

2: 80 percent / NaI / acetonitrile / 36 h / Heating

3: 87 percent / Et₃N / tetrahydrofuran / 8 h

With sodium tetrahydroborate; triethylamine; sodium iodide; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/ja00167a047

Reference yield:

2-chloro-3-(hydroxymethyl)quinoline (125917-60-4) → 2-iodo-3-(hydroxymethyl)quinoline benzoate ester (127183-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaI / acetonitrile / 36 h / Heating

2: 87 percent / Et₃N / tetrahydrofuran / 8 h

With triethylamine; sodium iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ja00167a047

upstream raw materials:

(2-iodoquinolin-3-yl)methanol

benzoyl chloride

2-chloro-3-quinoline carboxaldehyde

2-chloro-3-(hydroxymethyl)quinoline

Downstream raw materials:

2-benzoyl-3-(hydroxymethyl)quinoline

Refernces