10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride

Base Information

• Chemical Name: 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride
• CAS No.: 165611-16-5
• Molecular Formula: C₂₀H₁₃Cl₂NO₂
• Molecular Weight: 370.235
• Mol file: 165611-16-5.mol

Synonyms:10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride

Chemical Property of 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride

There total 4 articles about 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylic acid (143943-71-9) → 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride (165611-16-5)

Guidance literature:

With dmap; oxalyl dichloride; In ethyl acetate; at 60 ℃; for 3h;

DOI:10.1016/0040-4039(95)00387-R

Reference yield:

7-chloro-3,4-dihydroisoquinoline-1(2H)-thione (26406-59-7) → 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride (165611-16-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 2) NEt₃ / 1) CH₂Cl₂, 45 min

2: 83 percent / toluene / 8 h / Heating

3: 93 percent / NaOH / methanol; H₂O / 24 h / Heating

4: SOCl₂ / 1 h / Ambient temperature

With sodium hydroxide; thionyl chloride; triethylamine; In methanol; water; toluene;

DOI:10.1002/hlca.19900730402

Reference yield:

methyl 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylate (104604-73-1) → 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride (165611-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / NaOH / methanol; H₂O / 24 h / Heating

2: SOCl₂ / 1 h / Ambient temperature

With sodium hydroxide; thionyl chloride; In methanol; water;

DOI:10.1002/hlca.19900730402

upstream raw materials:

10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylic acid

7-chloro-3,4-dihydroisoquinoline-1(2H)-thione

methyl 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylate

9-chloro-5,6-dihydro-2-phenylthiazolo<2,3-a>isoquinolin-4-ium 3-oxide

Downstream raw materials:

10-chloro-N-<2-(dimethylamino)ethyl>-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizin-1-carboxamide hydrochloride

(S)-10-chloro-1-(3-ethoxypyrrolidin-1-yl)-3-phenyl-6,7-dihydro-4H-benzoquinolizin-4-one

10-chloro-1-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-6,7-dihydro-3-phenyl-4H-benzoquinolizin-4-one

10-chloro-6,7-dihydro-1-<(morpholin-4-yl)carbonyl>-3-phenyl-4H-benzoquinolizin-4-one