N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide

Base Information

• Chemical Name: N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide
• CAS No.: 1270965-97-3
• Molecular Formula: C₂₁H₂₆N₂O₅
• Molecular Weight: 386.448
• Mol file: 1270965-97-3.mol

Synonyms:N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide

Chemical Property of N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide

There total 4 articles about N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(3',4',5'-trimethoxybenzoyl)-1,2-phenylenediamine (404894-28-6) + pivaloyl chloride (3282-30-2) → N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide (1270965-97-3)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2010.11.043

Reference yield:

N-(3',4',5'-trimethoxybenzoyl)-2-nitroaniline (3940-81-6) → N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide (1270965-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium / ethanol

2: tetrahydrofuran / 0.5 h / 20 °C

With hydrogen; palladium; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2010.11.043

Reference yield:

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → N-{2-[(2,2-dimethylpropanoyl)amino]-phenyl}-3,4,5-trimethoxybenzamide (1270965-97-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / tetrahydrofuran / 20 °C

2: hydrogen; palladium / ethanol

3: tetrahydrofuran / 0.5 h / 20 °C

With pyridine; hydrogen; palladium; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2010.11.043

upstream raw materials:

N-(3',4',5'-trimethoxybenzoyl)-1,2-phenylenediamine

pivaloyl chloride

N-(3',4',5'-trimethoxybenzoyl)-2-nitroaniline

3,4,5-Trimethoxybenzoyl chloride