2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Base Information

• Chemical Name: 2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
• CAS No.: 157422-65-6
• Molecular Formula: C₂₇H₂₄F₃N₃O₅
• Molecular Weight: 527.5

Synonyms:2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Chemical Property of 2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

There total 33 articles about 2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-diethoxyacetophenone (6175-45-7) → 2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide (157422-65-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) acetic acid, 3 Angstroem molecular sieves, 2.) NaBH₃CN / 1.) ethanol, 1 h, 2.) ethanol, RT, 2 d

2: triethylamine / CH₂Cl₂

3: conc. sulfuric acid / diethyl ether / 3 h

4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

6: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

7: nitromethane, aluminum chloride / benzene / 1 h

8: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

9: 48 percent / methanol; diethyl ether

10: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

With dichloro-acetic acid; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; aluminium trichloride; sodium dihydrogen phosphate; nitromethane; 3 A molecular sieve; sulfuric acid; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/jm00001a014

Reference yield:

N-allyl-2,2-diethoxy-1-phenylethylamine (157422-73-6) → 2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide (157422-65-6)

Guidance literature:

Multi-step reaction with 9 steps

1: triethylamine / CH₂Cl₂

2: conc. sulfuric acid / diethyl ether / 3 h

3: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

4: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

5: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

6: nitromethane, aluminum chloride / benzene / 1 h

7: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

8: 48 percent / methanol; diethyl ether

9: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

With dichloro-acetic acid; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; aluminium trichloride; sodium dihydrogen phosphate; nitromethane; sulfuric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/jm00001a014

Reference yield:

9-Benzyl-1-oxo-2-(2-oxo-ethyl)-3-phenyl-2,9-dihydro-1H-β-carboline-8-carbonitrile (1026969-59-4) → 2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide (157422-65-6)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

2: 73 percent / 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

3: 83 percent / nitromethane, aluminum chloride / benzene / 1 h

4: 32 percent / sodium hypophosphite monohydrate, pyridine, acetic acid / Raney nickel / H₂O / 2 h / 60 °C

5: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

6: 48 percent / methanol; diethyl ether

7: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

With pyridine; dichloro-acetic acid; sodium chlorite; sodium dihydrogenphosphate; sodium hypophosphite; aluminium trichloride; sodium dihydrogen phosphate; nitromethane; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; nickel; In tetrahydrofuran; methanol; diethyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/jm00001a014

upstream raw materials:

2-<8-(methoxycarbonyl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

2,2-diethoxyacetophenone

3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

N-allyl-2,2-diethoxy-1-phenylethylamine

Downstream raw materials:

2-(9-Benzyl-8-cyano-1-oxo-3-phenyl-1,9-dihydro-β-carbolin-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide

2-(9-Benzyl-8-cyano-3-isopropyl-1-oxo-1,9-dihydro-β-carbolin-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide

2-<8-(methoxycarbonyl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

[(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 157422-65-6 2-(8-Methoxycarbonyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]-indol-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send