1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI)

Base Information

• Chemical Name: 1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI)
• CAS No.: 121507-34-4
• Molecular Formula: C6H11 N3 O
• Molecular Weight: 141.173
• Hs Code.: 2933199090
• Mol file: 121507-34-4.mol

Synonyms:3-Amino-5-isopropoxy-1H-pyrazole;5-Isopropoxy-1H-pyrazol-3-amine; 5-Isopropoxy-1H-pyrazole-3-amine;5-[(Propan-2-yl)oxy]-1H-pyrazol-3-amine

Chemical Property of 1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI)

Chemical Property:

• PSA: 63.93000
• LogP: 1.36030

Purity/Quality:

97% ^*data from raw suppliers

5-Isopropoxy-1H-pyrazol-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Isopropoxy-1H-pyrazol-3-amine pois involved with the synthesis and biol. evaluation of 2-(α-arylalkylamino)-4-(pyrazolylamino)pyrimidines as potent inhibitors of Trk kinases.

Technology Process of 1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI)

There total 3 articles about 1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

5-amino-2H-pyrazol-3-ol (53666-79-8) + isopropyl alcohol (67-63-0,8013-70-5) → 5-propan-2-yloxy-1H-pyrazol-3-amine (121507-34-4)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 48h;

DOI:10.1021/jm800343j

Reference yield: 6.0%

Cyanoacetohydrazide (140-87-4) + isopropyl alcohol (67-63-0,8013-70-5) → 3-isopropoxy-1H-pyrazol-5-amine (121507-34-4)

Guidance literature:

With methanesulfonic acid; at 82 ℃; for 40h;

Reference yield:

→ 5-propan-2-yloxy-1H-pyrazol-3-amine (121507-34-4)

Guidance literature:

upstream raw materials:

5-amino-2H-pyrazol-3-ol

isopropyl alcohol

Cyanoacetohydrazide

Downstream raw materials:

N-(5-fluoro-2-nitrophenyl)-5-isopropoxy-1H-pyrazol-3-amine

(S)-N-(1-(5-fluoropyrimidin-2-yl)ethyl)-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine

2,6-difluoro-N-(2-isopropoxypyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonamido)benzamide

N-(5-isopropoxy-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-3-yl)-3-(pyridin-2-ylsulfonyl)benzamide

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