(3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

Base Information

Chemical Name:(3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid
CAS No.:623582-51-4
Molecular Formula:C₁₈H₂₄N₂O₆
Molecular Weight:364.398
Hs Code.:

Synonyms:(3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

Suppliers and Price of (3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

There total 9 articles about (3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1033881-75-2
(3R,4R)-4-(benzyloxycarbonylamino)pyrrolidine-3-carboxylic acid

: 623582-51-4
(3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

Guidance literature:: di-tert-butyl dicarbonate; (3R,4R)-4-(benzyloxycarbonylamino)pyrrolidine-3-carboxylic acid; With water; sodium hydroxide; In tetrahydrofuran; for 16h;

With phosphoric acid; In water; pH=1;

Reference yield: 95.0%

: 623582-53-6
(3R,4R)-tert-butyl 3-(benzyloxycarbonyl)amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate

: 623582-51-4
(3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; sodium phosphate buffer; sodium hypochlorite; In water; acetonitrile; pH=6.7;
DOI:10.1021/jo034940o

Reference yield:

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 623582-51-4
(3R,4R)-4-(((benzyloxy)carbonyl) amino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran / 0 °C

2: diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

3: potassium carbonate / toluene / 20 °C

4: H₂ / Pd(OH)/C / 760 Torr

5: triethylamine / tetrahydrofuran / 0 °C

6: Jones reagent / acetone / 0 °C

With jones reagent; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; acetone; toluene;
DOI:10.1128/AAC.45.9.2563-2570.2001