Tert-butyl (3R)-3-{[(benzyloxy)carbonyl]aMino}-4-(hydroxyMethyl)

Base Information

Chemical Name:Tert-butyl (3R)-3-{[(benzyloxy)carbonyl]aMino}-4-(hydroxyMethyl)
CAS No.:623582-53-6
Molecular Formula:C18H26N2O5
Molecular Weight:350.415
Hs Code.:
Mol file:623582-53-6.mol

Synonyms:2H-Pyran-3-carboxylic acid,4-aminotetrahydro-,methyl ester,(3R,4R);(3R,4R)-tert-butyl 3-(benzyloxycarbonyl)amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate;(3R,4R)-methyl 4-aminotetrahydro-2H-pyran-3-carboxylate;(3R,4R)-4-AMINOTETRAHYDROPYRAN-3-CARBOXYLIC ACID METHYL ESTER;

Suppliers and Price of Tert-butyl (3R)-3-{[(benzyloxy)carbonyl]aMino}-4-(hydroxyMethyl)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Tert-butyl (3R)-3-{[(benzyloxy)carbonyl]aMino}-4-(hydroxyMethyl)

Chemical Property:

Melting Point:90-92 °C
Boiling Point:510.2±50.0 °C(Predicted)
PKA:11.81±0.40(Predicted)
PSA：91.59000
Density:1.22±0.1 g/cm3(Predicted)
LogP:2.28290

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Tert-butyl (3R)-3-{[(benzyloxy)carbonyl]aMino}-4-(hydroxyMethyl)

There total 6 articles about Tert-butyl (3R)-3-{[(benzyloxy)carbonyl]aMino}-4-(hydroxyMethyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 623582-53-6
(3R,4R)-tert-butyl 3-(benzyloxycarbonyl)amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 0 °C

2: diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

3: potassium carbonate / toluene / 20 °C

4: H₂ / Pd(OH)/C / 760 Torr

5: triethylamine / tetrahydrofuran / 0 °C

With hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1128/AAC.45.9.2563-2570.2001

Reference yield:

: 251948-88-6
N-allyl-N-(tert-butyloxycarbonyl)-glycinal

: 623582-53-6
(3R,4R)-tert-butyl 3-(benzyloxycarbonyl)amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / toluene / 20 °C

2: H₂ / Pd(OH)/C / 760 Torr

3: triethylamine / tetrahydrofuran / 0 °C

With hydrogen; potassium carbonate; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; toluene;
DOI:10.1128/AAC.45.9.2563-2570.2001