(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

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Chemical Name:(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide
CAS No.:1223498-42-7
Molecular Formula:C₁₇H₂₁BrN₄O₃S
Molecular Weight:441.349
Hs Code.:

Synonyms:(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

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Chemical Property of (R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

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Technology Process of (R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

There total 7 articles about (R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1223498-65-4
(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

: 1223498-42-7
(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

Guidance literature:: (R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide; With potassium carbonate; In methanol; at 20 ℃; for 1.5h;

With water; sodium chloride; In methanol;
DOI:10.1002/cmdc.201300096

Reference yield:

: 851008-29-2
(2R,3R)-3-[(5-bromo-2-chloropyrimidin-4-yl)oxy]butan-2-ol

: 1223498-42-7
(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / acetonitrile; water; 1,4-dioxane / 59 h / 80 °C

2: potassium carbonate / methanol / 1.5 h / 20 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; water; acetonitrile;
DOI:10.1002/cmdc.201300096

Reference yield:

: 851008-45-2
(R,S)-1-(cyclopropylsulfinyl)-4-nitrobenzene

: 1223498-42-7
(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

Guidance literature:: Multi-step reaction with 4 steps

1: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane / 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 6.25 h / 25 °C / 760.05 Torr

3: hydrogenchloride / acetonitrile; water; 1,4-dioxane / 59 h / 80 °C

4: potassium carbonate / methanol / 1.5 h / 20 °C

With hydrogenchloride; dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; hydrogen; magnesium oxide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/cmdc.201300096