(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

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Chemical Name:(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide
CAS No.:1223498-65-4
Molecular Formula:C₁₉H₂₀BrF₃N₄O₄S
Molecular Weight:537.357
Hs Code.:

Synonyms:(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

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Chemical Property of (R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

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Technology Process of (R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

There total 5 articles about (R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 851008-29-2
(2R,3R)-3-[(5-bromo-2-chloropyrimidin-4-yl)oxy]butan-2-ol

: 1223498-44-9
(R,S)-S-(4-aminophenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

: 1223498-65-4
(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; acetonitrile; at 80 ℃; for 59h;
DOI:10.1002/cmdc.201300096

Reference yield:

: 851008-45-2
(R,S)-1-(cyclopropylsulfinyl)-4-nitrobenzene

: 1223498-65-4
(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: Multi-step reaction with 3 steps

1: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane / 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 6.25 h / 25 °C / 760.05 Torr

3: hydrogenchloride / acetonitrile; water; 1,4-dioxane / 59 h / 80 °C

With hydrogenchloride; dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; hydrogen; magnesium oxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/cmdc.201300096

Reference yield:

: 1223498-43-8
(R,S)-S-cyclopropyl-S-(4-nitrophenyl)-N-(trifluoroacetyl)sulfoximide

: 1223498-65-4
(R,S)-S-{4-[(5-bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 6.25 h / 25 °C / 760.05 Torr

2: hydrogenchloride / acetonitrile; water; 1,4-dioxane / 59 h / 80 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201300096