methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate

Base Information

• Chemical Name: methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate
• CAS No.: 210366-13-5
• Molecular Formula: C₁₄H₁₃NO₄
• Molecular Weight: 259.262
• Mol file: 210366-13-5.mol

Synonyms:methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate

Chemical Property of methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate

There total 6 articles about methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(benzyloxy)-2-oxo-1,2-dihydropyridine-6-carboxylic acid (210366-15-7) + methyl iodide (74-88-4) → methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate (210366-13-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; acetonitrile; at 40 ℃; for 16h; Sealed tube;

Reference yield: 94.7%

benzyl bromide (100-39-0) + methyl-1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylate (210366-10-2) → methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate (210366-13-5)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating;

DOI:10.1002/jlcr.427

Reference yield: 74.0%

methyl 1-(benzyloxy)-6-oxo-1,2,3,6-tetrahydropyridine-2-carboxylate (1006364-82-4) → methyl 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylate (210366-13-5)

Guidance literature:

methyl 1-(benzyloxy)-6-oxo-1,2,3,6-tetrahydropyridine-2-carboxylate; With bromine; In dichloromethane; at 0 - 20 ℃;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.tet.2009.07.076

upstream raw materials:

benzyl bromide

methyl-1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylate

1,2-dihydro-1-hydroxy-2-oxopyridine-6-carboxylic acid

methyl 1-(benzyloxy)-6-oxo-1,2,3,6-tetrahydropyridine-2-carboxylate

Downstream raw materials:

1-(benzyloxy)-2-oxo-1,2-dihydropyridine-6-carboxylic acid

1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylic acid chloride