biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester

Base Information

Chemical Name:biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester
CAS No.:1253582-22-7
Molecular Formula:C₅₃H₇₀N₆O₇Si
Molecular Weight:931.26
Hs Code.:

biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester

Synonyms:biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester

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Chemical Property of biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester

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Technology Process of biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester

There total 11 articles about biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1253582-21-6
biphenyl-2-ylcarbamic acid 1-{2-[(3-aminopropyl)-methylcarbamoyl]ethyl}piperidin-4-yl ester

: 1253582-16-9
(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid

: 1253582-22-7
biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester

Guidance literature:: (3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

biphenyl-2-ylcarbamic acid 1-{2-[(3-aminopropyl)-methylcarbamoyl]ethyl}piperidin-4-yl ester; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 792917-99-8
methyl [3-(2-oxopropyl)phenyl]acetate

: 1253582-22-7
biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride; magnesium sulfate / dichloromethane

1.2: 0 °C

2.1: ammonium formate / palladium(II) hydroxide / ethanol / 1 h / 75 °C

3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 100 °C / Microwave irradiation

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

4.2: pH 6

5.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 20 °C

With water; hydrogen; ammonium formate; sodium tris(acetoxy)borohydride; magnesium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; palladium(II) hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1253582-22-7
biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetylamino]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 16 h / 40 °C

2.1: tributyltin methoxide / palladium diacetate; tris-(o-tolyl)phosphine / toluene / 6 h / 100 °C

3.1: sodium tris(acetoxy)borohydride; magnesium sulfate / dichloromethane

3.2: 0 °C

4.1: ammonium formate / palladium(II) hydroxide / ethanol / 1 h / 75 °C

5.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 100 °C / Microwave irradiation

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

6.2: pH 6

7.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

8.2: 20 °C

With sulfuric acid; water; hydrogen; ammonium formate; tributyltin methoxide; sodium tris(acetoxy)borohydride; magnesium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; palladium diacetate; palladium(II) hydroxide; tris-(o-tolyl)phosphine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;