(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid

Base Information

Chemical Name:(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid
CAS No.:1253582-16-9
Molecular Formula:C₂₈H₃₈N₂O₅Si
Molecular Weight:510.706
Hs Code.:

Synonyms:(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid

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Chemical Property of (3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid

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Technology Process of (3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid

There total 7 articles about (3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1253582-15-8
(3-{(S)-2-[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-(tert-butyldimethylsilanyloxy)ethylamino]propyl}phenyl)acetic acid

: 1253582-16-9
(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; water; for 1h; Inert atmosphere;

Reference yield:

: 792917-99-8
methyl [3-(2-oxopropyl)phenyl]acetate

: 1253582-16-9
(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride; magnesium sulfate / dichloromethane

1.2: 0 °C

2.1: ammonium formate / palladium(II) hydroxide / ethanol / 1 h / 75 °C

3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 100 °C / Microwave irradiation

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

4.2: pH 6

5.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / Inert atmosphere

With water; hydrogen; ammonium formate; sodium tris(acetoxy)borohydride; magnesium sulfate; triethylamine; lithium hydroxide; palladium 10% on activated carbon; palladium(II) hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1253582-16-9
(3-{(S)-2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}phenyl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 16 h / 40 °C

2.1: tributyltin methoxide / palladium diacetate; tris-(o-tolyl)phosphine / toluene / 6 h / 100 °C

3.1: sodium tris(acetoxy)borohydride; magnesium sulfate / dichloromethane

3.2: 0 °C

4.1: ammonium formate / palladium(II) hydroxide / ethanol / 1 h / 75 °C

5.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 100 °C / Microwave irradiation

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

6.2: pH 6

7.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / Inert atmosphere

With sulfuric acid; water; hydrogen; ammonium formate; tributyltin methoxide; sodium tris(acetoxy)borohydride; magnesium sulfate; triethylamine; lithium hydroxide; palladium 10% on activated carbon; palladium diacetate; palladium(II) hydroxide; tris-(o-tolyl)phosphine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; toluene;