N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide
• CAS No.: 1613144-16-3
• Molecular Formula: C₂₂H₂₀ClNO₅S
• Molecular Weight: 445.923

Synonyms:N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide

Chemical Property of N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide

There total 4 articles about N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-(2-hydroxy-phenyl)-toluene-4-sulfonamide (3897-39-0) + 2-bromo-1-(5-chloro-2-methoxyphenyl)-ethanone (111841-05-5) → N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide (1613144-16-3)

Guidance literature:

N-(2-hydroxy-phenyl)-toluene-4-sulfonamide; With potassium carbonate; In N,N-dimethyl-formamide; at -10 ℃; for 0.5h;

2-bromo-1-(5-chloro-2-methoxyphenyl)-ethanone; In N,N-dimethyl-formamide; at -10 ℃;

DOI:10.1039/c4cc02425g

Reference yield:

2-methoxy-5-chloroacetophenone (6342-64-9) → N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide (1613144-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(ll) bromide / ethyl acetate; chloroform / 8 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / -10 °C

2.2: -10 °C

With potassium carbonate; copper(ll) bromide; In chloroform; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1039/c4cc02425g

Reference yield:

2-amino-phenol (95-55-6) → N-(2-(5-chloro-2-methoxyphenyl)-2-oxoethyl)-N-(2-hydroxyphenyl)-4-methylbenzenesulfonamide (1613144-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 12 h / 0 - 28 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / -10 °C

2.2: -10 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c4cc02425g

upstream raw materials:

N-(2-hydroxy-phenyl)-toluene-4-sulfonamide

2-bromo-1-(5-chloro-2-methoxyphenyl)-ethanone

2-methoxy-5-chloroacetophenone

2-amino-phenol

Downstream raw materials:

benzo[d]oxazol-2-yl(5-chloro-2-methoxyphenyl)methanone

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