(E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one
CAS No.:1380281-62-8
Molecular Formula:C₂₃H₂₁F₂N₃O
Molecular Weight:393.436
Hs Code.:

Synonyms:(E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one

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Chemical Property of (E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one

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Technology Process of (E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one

There total 6 articles about (E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380281-61-7
1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)ethanone

: 36805-97-7
N,N-dimethylformamide di-tert-butyl acetal

: 1380281-62-8
(E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 4h;

Reference yield:

: 144025-03-6
2,4-difluorophenylboronic acid

: 1380281-62-8
(E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 2.5 h / 75 °C

2.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

3.1: sodium hydroxide; methanol / tetrahydrofuran / 18 h / 20 °C

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran / 0.5 h / 20 °C

4.2: 18 h / 20 °C

5.1: methylmagnesium bromide / diethyl ether; water; tetrahydrofuran / 20 °C / Cooling

6.1: N,N-dimethyl-formamide / 4 h / 60 °C

With 4-methyl-morpholine; methanol; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; methylmagnesium bromide; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1380281-57-1
2-bromo-6-(2,4-difluorophenyl)pyridine

: 1380281-62-8
(E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

2.1: sodium hydroxide; methanol / tetrahydrofuran / 18 h / 20 °C

3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: methylmagnesium bromide / diethyl ether; water; tetrahydrofuran / 20 °C / Cooling

5.1: N,N-dimethyl-formamide / 4 h / 60 °C

With 4-methyl-morpholine; methanol; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; methylmagnesium bromide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; palladium diacetate; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; toluene;