1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile

Base Information

Chemical Name:1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile
CAS No.:812674-83-2
Molecular Formula:C₂₄H₂₂F₂N₆
Molecular Weight:432.476
Hs Code.:

Synonyms:1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile

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Chemical Property of 1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile

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Technology Process of 1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile

There total 8 articles about 1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676601-94-8
1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9H-2,4,9-triaza-fluorene-5-carbonitrile

: 74-88-4
methyl iodide

: 812674-83-2
1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile

Guidance literature:: 1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9H-2,4,9-triaza-fluorene-5-carbonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.666667h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm0310129

Reference yield:

: 65610-13-1
3-fluoro-1,2-benzenedicarbonitrile

: 812674-83-2
1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: 19 percent / K₂CO₃ / acetonitrile / Heating

2.1: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

3.1: dimethylformamide / 100 °C

4.1: NH₃ / ethanol / 100 °C

5.1: Et₃N*HCl; POCl₃ / Heating

6.1: dimethylformamide / 100 °C

7.1: NaH / dimethylformamide / 0.67 h / 0 °C

7.2: dimethylformamide / 2 h / 20 °C

With dmap; ammonia; triethylamine hydrochloride; sodium hydride; potassium carbonate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0310129

Reference yield:

: 1-oxo-2,9-dihydro-1H-2,4,9-triaza-fluorene-5-carbonitrile

: 812674-83-2
1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,9-triaza-fluorene-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N*HCl; POCl₃ / Heating

2.1: dimethylformamide / 100 °C

3.1: NaH / dimethylformamide / 0.67 h / 0 °C

3.2: dimethylformamide / 2 h / 20 °C

With triethylamine hydrochloride; sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm0310129