5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Base Information

Chemical Name:5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one
CAS No.:75473-47-1
Molecular Formula:C₁₄H₁₀N₄O₅S
Molecular Weight:346.323
Hs Code.:

Synonyms:5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Chemical Property of 5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Technology Process of 5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

There total 10 articles about 5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 75473-34-6
5-(2-Methyl-3-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

: 75473-47-1
5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: With sulfuric acid; nitric acid; at -5 ℃; for 0.333333h;
DOI:10.1002/ardp.19803130704

Reference yield:

: 39053-41-3
2-methyl-3-nitrobenzoyl chloride

: 75473-47-1
5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) Mg, CCl₄ / 1.) EtOH, ether, reflux, 3 h, 2.) EtOH, ether, reflux, 10 min.

2: conc. H₂SO₄ / aq. acetic acid / 4 h / Heating

3: 99 percent / AlCl₃, Br₂ / CHCl₃ / 0.25 h / 50 °C

4: 64 percent / aq. ethanol / 1.5 h / 50 °C

5: 78 percent / Et₃N / dioxane / 0.75 h / Heating

6: K₂CO₃ / dioxane / 2 h / Ambient temperature

7: NaI / acetone / 1 h / Heating

8: 63 percent / conc. aq. NH₃ / CH₂Cl₂ / 48 h / Ambient temperature

9: 79 percent / isobutyric acid / 0.08 h / Heating

10: 57 percent / conc. H₂SO₄, conc. HNO₃ / 0.33 h / -5 °C

With tetrachloromethane; ammonium hydroxide; aluminium trichloride; sulfuric acid; bromine; nitric acid; potassium carbonate; magnesium; triethylamine; isobutyric Acid; sodium iodide; In 1,4-dioxane; ethanol; dichloromethane; chloroform; acetic acid; acetone;
DOI:10.1002/ardp.19803130704

Reference yield:

: 75473-11-9
1-(2-methyl-3-nitro-phenyl)ethanone

: 75473-47-1
5-(2-Methyl-3-nitro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / AlCl₃, Br₂ / CHCl₃ / 0.25 h / 50 °C

2: 64 percent / aq. ethanol / 1.5 h / 50 °C

3: 78 percent / Et₃N / dioxane / 0.75 h / Heating

4: K₂CO₃ / dioxane / 2 h / Ambient temperature

5: NaI / acetone / 1 h / Heating

6: 63 percent / conc. aq. NH₃ / CH₂Cl₂ / 48 h / Ambient temperature

7: 79 percent / isobutyric acid / 0.08 h / Heating

8: 57 percent / conc. H₂SO₄, conc. HNO₃ / 0.33 h / -5 °C

With ammonium hydroxide; aluminium trichloride; sulfuric acid; bromine; nitric acid; potassium carbonate; triethylamine; isobutyric Acid; sodium iodide; In 1,4-dioxane; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1002/ardp.19803130704