ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate

Base Information

Chemical Name:ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate
CAS No.:1192164-06-9
Molecular Formula:C₃₃H₄₂N₄O₄
Molecular Weight:558.721
Hs Code.:

Synonyms:ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate

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Chemical Property of ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate

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Technology Process of ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate

There total 8 articles about ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192164-07-0
5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1192164-06-9
ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate

Guidance literature:: 5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylic acid; glycine ethyl ester hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; ethanol; at 20 ℃; for 0.0833333h;

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 12h;

Reference yield:

: 1192164-02-5
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylate

: 1192164-06-9
ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / Inert atmosphere; Reflux

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

3.2: 20 °C

4.1: 4-methyl-morpholine / tetrahydrofuran; ethanol / 0.08 h / 20 °C

4.2: 12 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 4-methyl-morpholine; hydrogenchloride; water; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; ethyl acetate; toluene;

Reference yield:

: 1192163-99-7
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

: 1192164-06-9
ethyl ({[5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0.5 h / -78 °C

2.1: potassium carbonate; silver(l) oxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 3 h / Reflux; Inert atmosphere

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / Inert atmosphere; Reflux

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

5.2: 20 °C

6.1: 4-methyl-morpholine / tetrahydrofuran; ethanol / 0.08 h / 20 °C

6.2: 12 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 4-methyl-morpholine; hydrogenchloride; water; potassium carbonate; triethylamine; sodium hydroxide; silver(l) oxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; toluene;