N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide

Base Information

• Chemical Name: N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide
• CAS No.: 98217-46-0
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245.278
• Mol file: 98217-46-0.mol

Synonyms:N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide

Chemical Property of N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide

There total 2 articles about N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-propanoate (17946-01-9) → N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide (98217-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / cyclohexene / 10percent Pd/C / methanol / 3 h / Heating

2: Et₃N / tetrahydrofuran / 0.75 h / 0 °C

With triethylamine; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jo00221a005

Reference yield:

phenylpropyolic acid (637-44-5) → N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide (98217-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / 60 °C

2: Et₃N / tetrahydrofuran / 0.75 h / 0 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1021/jo00221a005

Reference yield: 48.0%

N-<2-(methoxycarbonyl)ethyl>-N-methyl-3-phenylpropynamide (98217-46-0) → N-methyl-3-phenylprop-2-ynamide (26218-49-5) + 4-(methoxycarbonyl)-1-methyl-2-oxo-3-benzylidenepyrrolidine + 4-(methoxycarbonyl)-1-methyl-2-oxo-3-benzyl-3-pyrroline

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at -69 ℃; for 0.25h;

DOI:10.1021/jo00221a005

upstream raw materials:

methyl 3-propanoate

phenylpropyolic acid

Downstream raw materials:

N-methyl-3-phenylprop-2-ynamide