26218-49-5Relevant academic research and scientific papers
Access to Triazolopiperidine Derivatives via Copper(I)-Catalyzed [3+2] Cycloaddition/Alkenyl C?N Coupling Tandem Reactions
Xiao, Guorong,Wu, Kaifu,Zhou, Wei,Cai, Qian
, p. 4988 - 4991 (2021/10/14)
A copper-catalyzed [3+2] cylcoaddition/ alkenyl C?N coupling tandem reaction was demonstrated. It provided a method for the formation of triazolopiperidine skeletons. (Figure presented.).
Intramolecular Michael Reactions. Addition to the α-Carbon of Ynamides
Rosenberg, Saul H.,Rapoport, Henry
, p. 3979 - 3982 (2007/10/02)
A number of substituted cinnamamides were synthesized to determine the feasibility of preparing 4-arylnipecotate derivatives via an intramolecular Michael reaction.With these substrates, β-elimination of the cinnamamide residue was the dominant reaction. 3-Phenylpropynamide substrates, however, underwent an unusual "anti-Michael" addition to the α-carbon of the acetylene to produce pyrrolidinones, whose structures were confirmed by independent synthesis.
