(S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide

Base Information

Chemical Name:(S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide
CAS No.:452305-68-9
Molecular Formula:C₂₇H₂₀Br₂N₆O₄S
Molecular Weight:684.368
Hs Code.:

Synonyms:(S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide

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Chemical Property of (S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide

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Technology Process of (S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide

There total 4 articles about (S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 452305-62-3
1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

: 452305-68-9
(S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 5 h / 20 °C

2: 88 percent / sodium azide / dimethylformamide / 12 h / 80 °C

3: CH₂Cl₂; trifluoroacetic acid / 20 °C

4: 1.9 g / triethylamine / dimethylformamide / 4 h

With dmap; sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1016/S0957-4166(02)00111-8

Reference yield:

: 452305-67-8
1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-azido]ethylcarbamate

: 452305-68-9
(S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂; trifluoroacetic acid / 20 °C

2: 1.9 g / triethylamine / dimethylformamide / 4 h

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1016/S0957-4166(02)00111-8

Reference yield:

: 452305-66-7
1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-[(4-methylphenyl)sulfonyl]oxy]ethylcarbamate

: 452305-68-9
(S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / sodium azide / dimethylformamide / 12 h / 80 °C

2: CH₂Cl₂; trifluoroacetic acid / 20 °C

3: 1.9 g / triethylamine / dimethylformamide / 4 h

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1016/S0957-4166(02)00111-8