2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester

Base Information

Chemical Name:2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester
CAS No.:425675-46-3
Molecular Formula:C₂₅H₃₁N₃O₄
Molecular Weight:437.539
Hs Code.:

Synonyms:2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester

Suppliers and Price of 2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester

There total 9 articles about 2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.6%

: 1128073-03-9
ethyl 2-(4-(4-(2-carbamoyl-2-(4-methylbenzyl)hydrazinyl)-4-oxobutyl)phenoxy)-2-methylpropanoate

: 425675-46-3
2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester

: 1128073-17-5
ethyl 2-methyl-2-(4-(4-(2-(4-methylbenzyl)hydrazinyl)-4-oxobutyl)phenoxy)propanoate

: 534568-00-8
C₂₅H₃₀N₂O₅

Guidance literature:: ethyl 2-(4-(4-(2-carbamoyl-2-(4-methylbenzyl)hydrazinyl)-4-oxobutyl)phenoxy)-2-methylpropanoate; With camphor-10-sulfonic acid; In toluene; at 100 ℃; for 3h; Inert atmosphere; Large scale reaction;

With sulfuric acid; In ethanol; toluene; at 80 ℃; for 2h; Inert atmosphere; Large scale reaction;
DOI:10.1021/op8002486

Reference yield: 55.2%

: 1128073-03-9
ethyl 2-(4-(4-(2-carbamoyl-2-(4-methylbenzyl)hydrazinyl)-4-oxobutyl)phenoxy)-2-methylpropanoate

: 425675-46-3
2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester

Guidance literature:: ethyl 2-(4-(4-(2-carbamoyl-2-(4-methylbenzyl)hydrazinyl)-4-oxobutyl)phenoxy)-2-methylpropanoate; With camphor-10-sulfonic acid; In ethyl acetate; for 6h; Reflux; Large scale;

In ethyl acetate; for 1h; Reflux; Large scale;
DOI:10.1021/op700040v

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 425675-46-3
2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C / 3345.86 Torr

3.1: isopropyl alcohol / 16 h / 20 °C

4.1: isopropyl alcohol

5.1: pyridine / ethyl acetate / 1 h / 20 °C / Large scale

6.1: camphor-10-sulfonic acid / ethyl acetate / 6 h / Reflux; Large scale

6.2: Amberlyst-15 resin / 1 h / Reflux; Large scale

With pyridine; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; hydrazine; In ethanol; ethyl acetate; isopropyl alcohol;
DOI:10.1021/op700040v