2-Methyl-2-[4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid

Base Information

• Chemical Name: 2-Methyl-2-[4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid
• CAS No.: 425671-29-0
• Molecular Formula: C23H27N3O4
• Molecular Weight: 409.485

Synonyms:LY-518674;Propanoic acid, 2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methyl-;2-Methyl-2-[4-[3-[1-(4-Methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid

Chemical Property of 2-Methyl-2-[4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 575.852°C at 760 mmHg
• Flash Point: 302.065°C
• Density: 1.21g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-2-[4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid

There total 28 articles about 2-Methyl-2-[4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester (425675-46-3) → LY 518674 (425671-29-0)

Guidance literature:

2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid ethyl ester; With sodium hydroxide; In water; at 25 ℃; for 6h; Inert atmosphere; Large scale reaction;

Inert atmosphere; Large scale reaction;

DOI:10.1021/op8002486

Reference yield: 83.0%

2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester (425674-22-2) → LY 518674 (425671-29-0)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 4h;

DOI:10.1021/jm034173l

Reference yield: 55.0%

C27H37N3O5 → LY 518674 (425671-29-0)

Guidance literature:

With methanesulfonic acid; In toluene; for 6h; Reflux;

DOI:10.1021/op700040v

upstream raw materials:

2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester

5-[3-(4-hydroxyphenyl)propyl]-2-(4-methylbenzyl)-2,4-dihydro-[1,2,4]triazol-3-one

chloroform

acetone

Downstream raw materials:

5-[3-[4-(2-hydroxy-1,1-dimethylethoxy)phenyl]propyl]-2-(4-methylbenzyl)-2,4-dihydro[1,2,4]triazol-3-one

2-(2-bromo-4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl]phenoxy)-2-methyl propionic acid

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