3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-hydroxy-4-pyridinecarboxamide

Base Information

Chemical Name:3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-hydroxy-4-pyridinecarboxamide
CAS No.:861895-91-2
Molecular Formula:C₁₄H₁₂Cl₂N₂O₂
Molecular Weight:311.167
Hs Code.:

Synonyms:3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-hydroxy-4-pyridinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-hydroxy-4-pyridinecarboxamide

Chemical Property:

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Technology Process of 3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-hydroxy-4-pyridinecarboxamide

There total 2 articles about 3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-hydroxy-4-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-(methoxymethoxy)-4-pyridine-carboxamide

: 861895-91-2
3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-hydroxy-4-pyridinecarboxamide

Guidance literature:: 3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-(methoxymethoxy)-4-pyridine-carboxamide; With hydrogenchloride; In diethyl ether; at 20 ℃; for 55h;

With sodium hydrogencarbonate; In diethyl ether; water;

Reference yield:

: 74115-12-1
5-chloropyridin-3-ol

: 861895-91-2
3-chloro-N-[(1S)-1-(4-chlorophenyl)ethyl]-5-hydroxy-4-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 18 h / 60 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 2 h / -70 °C

2.2: -70 - 23 °C

3.1: hydrogenchloride / diethyl ether / 55 h / 20 °C

With hydrogenchloride; n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; diethyl ether; acetonitrile;