methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate

Base Information

• Chemical Name: methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate
• CAS No.: 203917-98-0
• Molecular Formula: C₂₈H₂₆O₇
• Molecular Weight: 474.51
• Mol file: 203917-98-0.mol

Synonyms:methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate

Chemical Property of methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate

There total 9 articles about methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methoxyphenylboronic acid (5720-07-0) + methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(trifluoromethanesulfonyloxy)-2H-chromene-3-carboxylate (203919-37-3) → methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate (203917-98-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride; In 1,2-dimethoxyethane; for 3h; Heating;

DOI:10.1021/jm010382z

Reference yield: 64.0%

1-bromo-4-methoxy-benzene (104-92-7) + methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-methoxy-2H-chromene-3-carboxylate (477936-02-0) → methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate (203917-98-0) + [2-benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-yl]-(4-methoxy-phenyl)-methanone

Guidance literature:

1-bromo-4-methoxy-benzene; With magnesium; ethylene dibromide; In tetrahydrofuran; for 0.5h; Heating;

methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-methoxy-2H-chromene-3-carboxylate; In tetrahydrofuran; at 0 ℃; for 0.5h; Further stages.;

DOI:10.1021/jo0261092

Reference yield: 35.0%

4-methoxyphenyl magnesium bromide (13139-86-1) + methyl 2-(benzo[1,3]dioxol-5-yl)-4-chloro-6-isopropoxy-2H-chromene-3-carboxylate (203917-94-6) → methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(4-methoxy-phenyl)-2H-chromen-3-carboxylate (203917-98-0)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; ammonium chloride; iron(III) chloride; In tetrahydrofuran;

upstream raw materials:

4-methoxyphenylboronic acid

methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-(trifluoromethanesulfonyloxy)-2H-chromene-3-carboxylate

1-bromo-4-methoxy-benzene

methyl 2-(benzo[1,3]dioxol-5-yl)-6-isopropoxy-4-methoxy-2H-chromene-3-carboxylate

Downstream raw materials:

rac-S-1255