Ethanamine, 2-(3-fluorophenoxy)- (9CI)

Base Information

• Chemical Name: Ethanamine, 2-(3-fluorophenoxy)- (9CI)
• CAS No.: 120351-93-1
• Molecular Formula: C8H10 F N O
• Molecular Weight: 155.172
• Hs Code.: 2922299090
• Mol file: 120351-93-1.mol

Synonyms:Ethanamine, 2-(3-fluorophenoxy)- (9CI);2-(3-Fluorophenoxy)-1-ethanamine

Chemical Property of Ethanamine, 2-(3-fluorophenoxy)- (9CI)

Chemical Property:

• Vapor Pressure: 0.11mmHg at 25°C
• Refractive Index: 1.508
• Boiling Point: 220.9°Cat760mmHg
• Flash Point: 87.4°C
• PSA: 35.25000
• Density: 1.125g/cm³
• LogP: 1.86350
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Hygroscopic

Purity/Quality:

98%min ^*data from raw suppliers

2-(3-Fluorophenoxy)ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(3-Fluorophenoxy)ethylamine acts as a reagent in the synthesis of neuronal nitric oxide synthase inhibitors with improved cellular permeability. Dimethyltetrahydropyrazino purinediones preparation as adenosine receptor antagonists.

Technology Process of Ethanamine, 2-(3-fluorophenoxy)- (9CI)

There total 3 articles about Ethanamine, 2-(3-fluorophenoxy)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-(3-fluorophenoxy)ethyl)isoindoline-1,3-dione → 2-(3-fluorophenoxy)ethanamine (120351-93-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 50 ℃; for 4h;

DOI:10.1021/acsmedchemlett.8b00177

Reference yield:

1-(2-bromoethoxy)-3-fluorobenzene (85262-57-3) → 2-(3-fluorophenoxy)ethanamine (120351-93-1)

Guidance literature:

1-(2-bromoethoxy)-3-fluorobenzene; With 18-crown-6 ether; potassium phtalimide; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

With methylamine; In water; at 50 ℃; for 2h;

With sodium hydroxide; In water; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.0c00814

Reference yield:

3-fluorophenol (372-20-3) → 2-(3-fluorophenoxy)ethanamine (120351-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: hydrazine hydrate / ethanol / 4 h / 50 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1021/acsmedchemlett.8b00177

upstream raw materials:

3-fluorophenol

1-(2-bromoethoxy)-3-fluorobenzene

Downstream raw materials:

2-Bromo-N-[2-(3-fluoro-phenoxy)-ethyl]acetamide

5-[2-(3-Fluoro-phenoxy)-ethylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

Refernces

• 1、 Li, Linhu,Lv, Kai,Yang, Yupeng,Sun, Jingquan,Tao, Zeyu,Wang, Apeng,Wang, Bin,Wang, Hongjian,Geng, Yunhe,Liu, Mingliang,Guo, Huiyuan,Lu, Yu. "Identification of N-Benzyl 3,5-Dinitrobenzamides Derived from PBTZ169 as Antitubercular Agents". . p. 741 - 745. Retrieved 2018/07/05.