C₆₀H₁₀₄N₆O₁₄Si₂

Base Information

Chemical Name:C₆₀H₁₀₄N₆O₁₄Si₂
CAS No.:267001-38-7
Molecular Formula:C₆₀H₁₀₄N₆O₁₄Si₂
Molecular Weight:1189.69
Hs Code.:

C<sub>60</sub>H<sub>104</sub>N<sub>6</sub>O<sub>14</sub>Si<sub>2</sub>

Synonyms:C₆₀H₁₀₄N₆O₁₄Si₂

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Chemical Property of C₆₀H₁₀₄N₆O₁₄Si₂

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Technology Process of C₆₀H₁₀₄N₆O₁₄Si₂

There total 11 articles about C₆₀H₁₀₄N₆O₁₄Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 267001-37-6
Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

: 267001-38-7
C₆₀H₁₀₄N₆O₁₄Si₂

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1021/jo991523w

Reference yield:

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 267001-38-7
C₆₀H₁₀₄N₆O₁₄Si₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: Cs₂CO₃ / methanol / 2 h / 20 °C

1.2: 94 percent / dimethylformamide / 18 h / 20 °C

2.1: Et₂NH / acetonitrile / 0.5 h / 20 °C

3.1: 800 mg / BOP; N-methylmorpholine / CH₂Cl₂ / 72 h / 20 °C

4.1: Et₂NH / acetonitrile / 0.5 h / 20 °C

5.1: 116 mg / Et₃N; BOP / CH₂Cl₂ / 3.5 h / 20 °C

6.1: Et₂NH / acetonitrile / 0.5 h / 20 °C

7.1: 55 mg / DIPEA; BroP / CH₂Cl₂ / 48 h / 20 °C

8.1: 84 percent / piperidine / CH₂Cl₂ / 0.25 h / 20 °C

With piperidine; 4-methyl-morpholine; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile; 1.1: Metallation / 1.2: Esterification / 2.1: Substitution / 3.1: Condensation / 4.1: Substitution / 5.1: Condensation / 6.1: Substitution / 7.1: Condensation / 8.1: Substitution;
DOI:10.1021/jo991523w

Reference yield:

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

: 267001-38-7
C₆₀H₁₀₄N₆O₁₄Si₂

Guidance literature:: Multi-step reaction with 8 steps

1: DCC / CH₂Cl₂ / 0 - 20 °C

2: 704 mg / DIPEA / dimethylformamide / 17 h / 0 - 20 °C

3: 800 mg / BOP; N-methylmorpholine / CH₂Cl₂ / 72 h / 20 °C

4: Et₂NH / acetonitrile / 0.5 h / 20 °C

5: 116 mg / Et₃N; BOP / CH₂Cl₂ / 3.5 h / 20 °C

6: Et₂NH / acetonitrile / 0.5 h / 20 °C

7: 55 mg / DIPEA; BroP / CH₂Cl₂ / 48 h / 20 °C

8: 84 percent / piperidine / CH₂Cl₂ / 0.25 h / 20 °C

With piperidine; 4-methyl-morpholine; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Esterification / 2: Condensation / 3: Condensation / 4: Substitution / 5: Condensation / 6: Substitution / 7: Condensation / 8: Substitution;
DOI:10.1021/jo991523w