[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid

Base Information

• Chemical Name: [4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid
• CAS No.: 878206-29-2
• Molecular Formula: C₁₈H₂₃BClNO₃
• Molecular Weight: 347.65

Synonyms:[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid

Chemical Property of [4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid

Chemical Property:

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Technology Process of [4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid

There total 1 articles about [4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-chloro-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)benzamide (301672-80-0) → [4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid (878206-29-2)

Guidance literature:

5-bromo-2-chloro-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)benzamide; With methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.166667h;

With Triisopropyl borate; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane; at -78 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; pentane; at 20 ℃; for 16h;

Reference yield:

[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid (878206-29-2) + methyl 2-(2-bromophenyl)acetate (57486-69-8) → 4'-chloro-3'-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]-[1,1'-biphenyl]-2-acetic acid methyl ester

Guidance literature:

With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; at 40 ℃; for 1h;

Reference yield:

[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid (878206-29-2) + methyl 2-bromo-5-fluorobenzoate (6942-39-8) → 4'-chloro-4-fluoro-3'-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]-[1,1'-biphenyl]-2-carboxylic acid methyl ester

Guidance literature:

With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; at 70 ℃; for 1h;

upstream raw materials:

5-bromo-2-chloro-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)benzamide

Downstream raw materials:

4-chloro-4'-hydroxy-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)-[1,1'-biphenyl]-3-carboxamide

2-chloro-5-(3-formyl-1-methyl-1H-pyrazol-4-yl)-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)benzamide

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