301672-80-0

Upstream product

• 17768-41-1 adamantylmethylamine 
• 21900-52-7 5-bromo-2-chloro-benzoyl chloride 
• 79-37-8 oxalyl dichloride 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 

Downstream Products

• 878206-29-2 [4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]boronic acid 
• 301673-02-9 2-chloro-5-(2-hydroxyethyl)-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide 
• 301671-99-8 (+/-)-5-(3-Amino-1-piperidinyl)-2-chloro-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide 
• 301672-81-1 2-chloro-5-formyl-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)benzamide 
• 301672-63-9 2-Chloro-5-[(E)-3-piperidinylidenemethyl]-N-(tricyclo[3.3.1.13.7]dec-1-ylmethyl)-benzamide 
• 301673-03-0 2-chloro-5-(2-oxoethyl)-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide 
• 301673-13-2 2-chloro-5-[(E)-(5,6-dihydro-3(4H)-pyridinylidene)methyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide 
• 301672-84-4 [4-[[[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-methyl]amino]cyclohexyl]-carbamic acid, 1,1-dimethylethyl ester 
• 301672-83-3 [[4-[[[4-Chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methyl]amino]cyclohexyl]methyl]-carbamic acid, 1,1-dimethylethyl ester 

Relevant academic research and scientific papers

Discovery of potent and selective adamantane-based small-molecule P2X 7 receptor antagonists/interleukin-1β inhibitors

A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of t

Adamantane derivatives

The invention provides compounds of general formula in which m, A, R1and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.