57486-69-8

Basic information

• Product Name: METHYL 2-(2-BROMOPHENYL)ACETATE
• Synonyms: (2-BROMO-PHENYL)-ACETIC ACID METHYL ESTER;Methyl 2-bromophenylacetate;METHYL 2-(2-BROMOPHENYL)ACETATE;Methyl 2-(2-bromophenyl)acetate 98%;Benzeneacetic acid,2-bromo-, methyl ester;Methyl 2-bromophenylacetate 98%;(2-BroMophenyl)Methyl acetate;2-Bromobenzeneacetic acid methyl ester
• CAS NO: 57486-69-8
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• Product Categories: blocks;Bromides;Carboxes;Aromatic Building Blocks
• Mol File: 57486-69-8.mol
• Article Data: 55

Chemical Properties

• Boiling Point: 264℃
• Flash Point: 114℃
• Appearance: /
• Density: 1.445
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Keep Cold
• CAS DataBase Reference: METHYL 2-(2-BROMOPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(2-BROMOPHENYL)ACETATE(57486-69-8)
• EPA Substance Registry System: METHYL 2-(2-BROMOPHENYL)ACETATE(57486-69-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 57486-69-8(Hazardous Substances Data)

Usage

Uses

Methyl 2-(2-bromophenyl)acetate is a reagent in the synthesis of 2,3,3a,12b-Tetradehydro Asenapine (T291630). 2,3,3a,12b-Tetradehydro Asenapine is a degredation product of Asenapine (A788000), a combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.

InChI:InChI=1/C9H9BrO2/c1-12-9(11)6-7-4-2-3-5-8(7)10/h2-5H,6H2,1H3

Upstream product

• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 18698-97-0 ortho-bromophenylacetic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 67-56-1 methanol 
• 1829-37-4 o-bromophenyl acetate 
• 101-41-7 benzeneacetic acid methyl ester 
• 55116-09-1 2-bromophenylacetyl chloride 
• 74-88-4 methyl iodide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 7664-93-9 sulfuric acid 

Downstream Products

• 20921-96-4 methyl 2-(2-cyanophenyl)acetate 
• 917026-14-3 (4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methyl-phenyl]-propyl}-biphenyl-2-yl)-acetic acid methyl ester 
• 660855-46-9 methyl [5-(hydroxymethyl)imidazol-1-yl]phenylacetate 
• 949168-30-3 1-amino-3-(2-bromophenyl)piperidin-2-one 
• 1350840-28-6 methyl 2-(2-bromophenyl)-5-methylhexanoate 
• 1350840-13-9 2-(2-bromophenyl)-N-methoxypropanamide 
• 1350840-14-0 2-(2-bromophenyl)-N-methoxy-5-methylhexanamide 
• 1350840-15-1 2-(2-bromophenyl)-3-cyclohexyl-N-methoxypropanamide 
• 1350840-24-2 3-cyclohexylmethyl-1-methoxyindolin-2-one 
• 1350840-27-5 3,3'-bis(cyclohexylmethyl)-1,1'-dimethoxy-3,3'-biindoline-2,2'-dione 
• 1350840-30-0 2-(2-bromophenyl)-5-methylhexanoic acid 
• 1350840-31-1 2-(2-bromophenyl)-3-cyclohexylpropanoic acid 
• 153184-13-5 2-bromo-α-methylbenzeneacetic acid 
• 1350840-29-7 methyl 2-(2-bromophenyl)-3-cyclohexylpropanoate 

Relevant articles and documents

Intramolecular Anti-Carbolithiation of Alkynes: Stereo-Directing Effect of Lithium-Coordinating Substituents

This paper presents the results of our investigations on the stereochemical course of intramolecular carbolithiation of alkynes. It is shown that the presence of a lithium-chelating propargylic substituent completely reverses the otherwise favored syn-pro

Borylation of Unactivated C(sp3)-H Bonds with Bromide as a Traceless Directing Group

A palladium-catalyzed alkyl C-H borylation with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a β-all-carbon quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance.

B(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes

Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes is described in the presence of 10 mol% of B(C6F5)3. These reactions provide N1-alkylated benzotriazoles in good to excellent yields and this protocol is successfully adapted to gram-scale syntheses as well as a derivative with antimicrobial activity.