(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

Base Information

Chemical Name:(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile
CAS No.:1313758-37-0
Molecular Formula:C₁₇H₁₂F₆N₂O
Molecular Weight:374.285
Hs Code.:

Synonyms:(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

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Chemical Property of (R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

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Technology Process of (R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

There total 2 articles about (R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 7677-24-9
trimethylsilyl cyanide

: 1253518-97-6
(Z)-4-methoxy-N-(2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethylidene)aniline

: 1313758-37-0
(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; C₂₉H₃₀F₆N₄O₂; In toluene; at 25 ℃; for 48h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol201316z

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1263498-93-6
4-methoxy-N-(2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethylidene)aniline

: 1263499-22-4
(S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

: 1313758-37-0
(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

Guidance literature:: With (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-(diphenylphosphaneyl)-3,3-dimethylbutan-2-yl)thiourea; acrylic acid methyl ester; In dichloromethane; at -20 ℃; for 24h; Overall yield = 88 percent; enantioselective reaction;
DOI:10.1039/c9cc09151c