(S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

Base Information

Chemical Name:(S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile
CAS No.:1263499-22-4
Molecular Formula:C₁₇H₁₂F₆N₂O
Molecular Weight:374.285
Hs Code.:

Synonyms:(S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

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Technology Process of (S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

There total 2 articles about (S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 7677-24-9
trimethylsilyl cyanide

: 1263498-93-6
4-methoxy-N-(2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethylidene)aniline

: 1263499-22-4
(S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

Guidance literature:: With isopropyl alcohol; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In 1,2-dichloro-ethane; at 20 ℃; for 312h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/adsc.201000666

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1263498-93-6
4-methoxy-N-(2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethylidene)aniline

: 1263499-22-4
(S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

: 1313758-37-0
(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)propanenitrile

Guidance literature:: With (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-(diphenylphosphaneyl)-3,3-dimethylbutan-2-yl)thiourea; acrylic acid methyl ester; In dichloromethane; at -20 ℃; for 24h; Overall yield = 88 percent; enantioselective reaction;
DOI:10.1039/c9cc09151c