[Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester

Base Information

• Chemical Name: [Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester
• CAS No.: 99686-09-6
• Molecular Formula: C₁₂H₁₆F₃O₃PS
• Molecular Weight: 328.292
• Mol file: 99686-09-6.mol

Synonyms:[Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester

Chemical Property of [Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester

There total 1 articles about [Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O,O'-diethyl thiophosphonate (999-01-9) + 4-Trifluoromethylbenzaldehyde (455-19-6) → [Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester (99686-09-6)

Guidance literature:

With triethylamine; at 55 - 60 ℃; for 2h; Yield given;

DOI:10.1021/jo00351a002

Reference yield: 86.0%

methanesulfonyl chloride (124-63-0) + [Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester (99686-09-6) → Methanesulfonic acid (diethoxy-thiophosphoryl)-(4-trifluoromethyl-phenyl)-methyl ester (99668-19-6)

Guidance literature:

With triethylamine; In dichloromethane; at -40 - 0 ℃;

DOI:10.1021/jo00351a002

Reference yield:

[Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester (99686-09-6) → (Mercapto-phenyl-methyl)-phosphonic acid diethyl ester (70660-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / triethylamine / CH₂Cl₂ / -40 - 0 °C

2: 17 g / acetic anhydride, NaOAc / 19 h / 80 °C

With sodium acetate; acetic anhydride; triethylamine; In dichloromethane;

DOI:10.1021/jo00351a002

upstream raw materials:

O,O'-diethyl thiophosphonate

4-Trifluoromethylbenzaldehyde

Downstream raw materials:

Methanesulfonic acid (diethoxy-thiophosphoryl)-(4-trifluoromethyl-phenyl)-methyl ester

(Mercapto-phenyl-methyl)-phosphonic acid diethyl ester