4,5-dimethoxy-2-methylbenzyl cyanide

Base Information

• Chemical Name: 4,5-dimethoxy-2-methylbenzyl cyanide
• CAS No.: 7537-09-9
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 7537-09-9.mol

Synonyms:4,5-dimethoxy-2-methylbenzyl cyanide

Chemical Property of 4,5-dimethoxy-2-methylbenzyl cyanide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-dimethoxy-2-methylbenzyl cyanide

There total 6 articles about 4,5-dimethoxy-2-methylbenzyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(chloromethyl)-4,5-dimethoxy-2-methylbenzene (7537-05-5) + potassium cyanide (151-50-8) → 4,5-dimethoxy-2-methylbenzyl cyanide (7537-09-9)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; In water; benzene;

DOI:10.3987/R-1987-10-2683

Reference yield:

1,2-dimethoxy-4-methylbenzene (494-99-5) → 4,5-dimethoxy-2-methylbenzyl cyanide (7537-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / CH₃COOH / Ambient temperature

2: 83 percent / benzyltriethylammonium chloride / benzene; H₂O

With N-benzyl-N,N,N-triethylammonium chloride; acetic acid; In water; benzene;

DOI:10.3987/R-1987-10-2683

Reference yield:

sodium cyanide (773837-37-9) + C13H22NO2(1+)*I(1-) → 4,5-dimethoxy-2-methylbenzyl cyanide (7537-09-9)

Guidance literature:

With 18-crown-6 ether; In N,N-dimethyl-formamide;

DOI:10.1021/jm9000242

upstream raw materials:

1-(chloromethyl)-4,5-dimethoxy-2-methylbenzene

potassium cyanide

formaldehyd

1,2-dimethoxy-4-methylbenzene

Downstream raw materials:

4,5-dimethoxy-2-methyl-phenethylamine

(E)-2-(4,5-Dimethoxy-2-methyl-phenyl)-5-phenyl-pent-4-enenitrile

2-(4,5-Dimethoxy-2-methyl-phenyl)-3-oxo-butyronitrile

3-Bromo-4-(3,4-dimethoxy-phenyl)-5,6-dimethoxy-8-methyl-naphthalene-1-carbonitrile