[(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate]

Base Information

• Chemical Name: [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate]
• CAS No.: 176970-13-1
• Molecular Formula: C₁₁H₂₃NO₈S₂
• Molecular Weight: 361.438
• Mol file: 176970-13-1.mol

Synonyms:[(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate]

Chemical Property of [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate]

There total 1 articles about [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nim-triphenylmethyl-L-histidine methyl ester (62715-28-0) → (+)-Methyl (2S)-2-{(3S)-3-[(tert-butoxycarbonyl)amino]pyrrolidinyl}-3-(1-trityl-1H-imidazol-4-yl)Propanoate (607376-87-4) + [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate] (176970-13-1)

Guidance literature:

In methanol; dichloromethane;

Reference yield: 53.0%

1,2-bis(4-methoxybenzyl)diselane (62212-22-0) + [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate] (176970-13-1) → (S)-2-((tert-butoxycarbonyl)amino)-4-((4-methoxybenzyl)selanyl)-butyl methanesulfonate

Guidance literature:

1,2-bis(4-methoxybenzyl)diselane; With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 ℃; for 0.166667h; Inert atmosphere;

[(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate]; In tetrahydrofuran; ethanol; at 20 - 50 ℃; for 2.33333h; Inert atmosphere;

DOI:10.1002/chem.201902230

Reference yield: 43.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate] (176970-13-1) → tert-butyl ((S)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 45 ℃; for 23h;

upstream raw materials:

N^im-triphenylmethyl-L-histidine methyl ester

Downstream raw materials:

(S)-1-benzyl-3-(tert-butoxycarbonylamino)pyrrolidine

3(S)-(tert-butoxycarbonylamino)pyrrolidine

(S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate

Refernces