(S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide

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Chemical Name:(S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide
CAS No.:1053258-74-4
Molecular Formula:C₃₉H₄₇FN₂O₄Si
Molecular Weight:654.897
Hs Code.:

Synonyms:(S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide

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Chemical Property of (S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide

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Technology Process of (S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide

There total 6 articles about (S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132388-60-4,200625-96-3
(S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid

: 1053258-74-4
(S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methylmorpholine / tetrahydrofuran / 20 h / -10 °C

2: NaBH₄ / H₂O / 5 h / 23 °C

3: 7.6 g / imidazole / dimethylformamide

4: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

5: i-Pr₂NEt; HATU / dimethylformamide / 23 °C

With 4-methyl-morpholine; 1H-imidazole; sodium tetrahydroborate; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1053258-74-4
(S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 7.6 g / imidazole / dimethylformamide

2: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

3: i-Pr₂NEt; HATU / dimethylformamide / 23 °C

With 1H-imidazole; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k

Reference yield:

: 199006-31-0
(1S)-[1-hydroxymethyl-3-(tritylcarbamoyl)propyl]carbamic acid benzyl ester

: 1053258-74-4
(S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(R)-3-(4-fluoro-phenyl)-2-hydroxy-propionylamino]-pentanoic acid trityl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 7.6 g / imidazole / dimethylformamide

2: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

3: i-Pr₂NEt; HATU / dimethylformamide / 23 °C

With 1H-imidazole; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k