Technology Process of (5α,6β,17β)-17-(benzyloxymethyl)-6-methoxy-androstan-3-one
There total 9 articles about (5α,6β,17β)-17-(benzyloxymethyl)-6-methoxy-androstan-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chromium(VI) oxide; sulfuric acid;
In
[(2)H6]acetone;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: tetrahydrofuran / 3 h / Reflux
2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 15 h / 20 °C
2.2: 2 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 12 h / Reflux
4.1: borane-THF / tetrahydrofuran / 3 h / 0 °C
4.2: 3 h / 20 °C
5.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
5.2: 3 h / Reflux
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C
7.1: sodium hydride / tetrahydrofuran; mineral oil / 14 h / 60 °C
8.1: hydrogenchloride / water; methanol / 8 h / 20 °C
9.1: sulfuric acid; chromium(VI) oxide / [(2)H6]acetone / 0 °C
With
chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; borane-THF; sulfuric acid; sodium hydride; 9-bora-bicyclo[3.3.1]nonane; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; [(2)H6]acetone; dichloromethane; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: borane-THF / tetrahydrofuran / 3 h / 0 °C
1.2: 3 h / 20 °C
2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
2.2: 3 h / Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 14 h / 60 °C
5.1: hydrogenchloride / water; methanol / 8 h / 20 °C
6.1: sulfuric acid; chromium(VI) oxide / [(2)H6]acetone / 0 °C
With
chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; borane-THF; sulfuric acid; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; [(2)H6]acetone; dichloromethane; water; mineral oil;
