Technology Process of (3α,5α,6β,17β)-17-(benzyloxymethyl)-6-methoxy-androstan-3-ol
There total 10 articles about (3α,5α,6β,17β)-17-(benzyloxymethyl)-6-methoxy-androstan-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(5α,6β,17β)-17-(benzyloxymethyl)-6-methoxy-androstan-3-one;
With
potassium tri-sec-butyl-borohydride;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 12 h / Reflux
2.1: borane-THF / tetrahydrofuran / 3 h / 0 °C
2.2: 3 h / 20 °C
3.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
3.2: 3 h / Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C
5.1: sodium hydride / tetrahydrofuran; mineral oil / 14 h / 60 °C
6.1: hydrogenchloride / water; methanol / 8 h / 20 °C
7.1: sulfuric acid; chromium(VI) oxide / [(2)H6]acetone / 0 °C
8.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 2 h / -78 °C
8.2: 2 h / 0 - 20 °C
With
chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; borane-THF; sulfuric acid; sodium hydride; potassium tri-sec-butyl-borohydride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; [(2)H6]acetone; dichloromethane; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: borane-THF / tetrahydrofuran / 3 h / 0 °C
1.2: 3 h / 20 °C
2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
2.2: 3 h / Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 14 h / 60 °C
5.1: hydrogenchloride / water; methanol / 8 h / 20 °C
6.1: sulfuric acid; chromium(VI) oxide / [(2)H6]acetone / 0 °C
7.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 2 h / -78 °C
7.2: 2 h / 0 - 20 °C
With
chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; borane-THF; sulfuric acid; sodium hydride; potassium tri-sec-butyl-borohydride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; [(2)H6]acetone; dichloromethane; water; mineral oil;
