N₁-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N₂-(2-hydroxyethyl)qlycinamide

Base Information

• Chemical Name: N₁-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N₂-(2-hydroxyethyl)qlycinamide
• CAS No.: 913570-33-9
• Molecular Formula: C₂₁H₂₃ClN₄O₃
• Molecular Weight: 414.892

Synonyms:N₁-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N₂-(2-hydroxyethyl)qlycinamide

Chemical Property of N₁-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N₂-(2-hydroxyethyl)qlycinamide

Chemical Property:

Purity/Quality:

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Technology Process of N₁-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N₂-(2-hydroxyethyl)qlycinamide

There total 2 articles about N₁-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N₂-(2-hydroxyethyl)qlycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H17Cl2N3O2 + ethanolamine (141-43-5) → N1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N2-(2-hydroxyethyl)qlycinamide (913570-33-9)

Guidance literature:

In Isopropyl acetate; at 80 ℃; for 5h;

Reference yield:

1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-amine (913570-34-0) → N1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N2-(2-hydroxyethyl)qlycinamide (913570-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydrogencarbonate / Isopropyl acetate; water / 0.5 h / 20 °C

2: Isopropyl acetate / 5 h / 80 °C

With potassium hydrogencarbonate; In Isopropyl acetate; water;

Reference yield:

N1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-N2-(2-hydroxyethyl)qlycinamide (913570-33-9) → 1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2-piperazinone (913570-38-4)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 4h;

upstream raw materials:

ethanolamine

1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-amine

Downstream raw materials:

1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2-piperazinone

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