1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime

Base Information

Chemical Name:1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime
CAS No.:1416164-55-0
Molecular Formula:C₂₄H₂₈ClNO₇
Molecular Weight:477.942
Hs Code.:

Synonyms:1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime

Suppliers and Price of 1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime

There total 21 articles about 1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1416165-46-2
(1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-(1-(ethoxyimino)ethyl)benzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2.3,4-triyl triacetate

: 1416164-55-0
1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 1h;

Reference yield:

: 864070-18-8
4-(5-bromo-2-chlorobenzyl)phenol

: 1416164-55-0
1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime

Guidance literature:: Multi-step reaction with 13 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C

2.3: 16 h / 20 °C

3.1: leutidine / 12 h / 0 - 20 °C

4.1: collidine / dimethyl sulfoxide / 0.75 h / 150 °C

5.1: sodium ethanolate / ethanol / 20 h / 55 °C

5.2: 0.33 h

6.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

7.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

8.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 90 °C

9.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

10.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

11.1: formic acid / 0.5 h / 100 °C

12.1: pyridine / ethanol / 4 h / 80 °C / Inert atmosphere

13.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C

With pyridine; dmap; n-butyllithium; formic acid; 1,3-dimethylbarbituric acid; lithium hydroxide monohydrate; water; sodium ethanolate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexanes; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 10.1: Sonogashira Coupling;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1416164-55-0
1-(4-(2-chloro-5-((1S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-5-yl)benzyl)phenyl)ethanone O-ethyl oxime

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere

2: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Inert atmosphere

3: pyridine / ethanol / 4 h / 80 °C / Inert atmosphere

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C

With pyridine; lithium hydroxide monohydrate; water; potassium acetate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;